The dried bark of cascara has actually been employed for hundreds of years like a laxative, first from the indigenous peoples with the Pacific Northwest, after which by white settlers. The substances mostly answerable for the laxative motion are classified as the hydroxyanthracene glycosides (particularly cascarosides A, B, C and https://clicky.blogsky.com/1398/07/05/post-16/%da%a9%d8%a7%d8%b3%da%a9%d8%a7%d8%b1%d8%a7-Cascara-%da%86%db%8c%d9%87%d8%9f