Substitution at R3 by using a halogen or alkoxy group (74f–74i) resulted in a slight increase in mobile potency While using the halide analogs (74g–h) showing highest the potency in the group. Further more optimization brought about the discovery of 74i–j, with 74k as probably the most active compound from https://andrevpeth.blogdanica.com/31372747/5-simple-statements-about-indazole-amide-explained