The concomitant use of TYLENOL® with Codeine with all CYP3A4 inducers or discontinuation of a CYP3A4 inhibitor could result in lower codeine concentrations, increased norcodeine amounts, and fewer metabolism through CYP2D6 with resultant reduced morphine ranges. Your doctor or pharmacist gives you the manufacturer's affected individual facts sheet (Medication Information) https://wockusa.com/product/mdma-crystals/