There is a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to minimize afferent pain transmission and develop analgesia. Consequently, medication like clonidine that focus on alpha-2 receptors can impact the transmission of ache. Clonidine is dispersed in breast milk; https://rowanklbuo.luwebs.com/32741280/the-2-minute-rule-for-onolidine