We shown that, in distinction to classical opioid receptors, ACKR3 won't induce classical G protein signaling and is not modulated by the classical prescription or analgesic opioids, like morphine, fentanyl, or buprenorphine, or by nonselective opioid antagonists such as naloxone. As an alternative, we established that LIH383, an ACKR3-selective https://franciscow061jsv3.wiki-cms.com/user