Discovery of the cGAS-STING Pathway The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway was first discovered in 2013 and identified as a key innate immune sensing mechanism for detecting cytoplasmic DNA. It was found that cGAS acts as a cytosolic DNA sensor that detects foreign or aberrant DNA through binding and synthesis of the second messenger cyclic ... https://www.coherentmi.com/blog/the-emerging-cgas-sting-pathway-is-poised-for-growth-135